Menaquinone, and the presence in the cluster of four putative menaquinoneīiosynthetic genes, suggests a connection between the biosynthesis pathways ofīoth compounds. The structural resemblance of the NQ moiety to PM100118 has been discovered, this is, to our knowledge, the first insight ConclusionsĪlthough a number of compounds structurally related to PM100117 and Of PM100117 and PM100118 structural analogues showing an enhanced in vitroĬytotoxic activity relative to the parental products. Mutant in a gene coding for a putative cytochrome P450 has led to the production To be involved in the biosynthesis of this moiety. Likewise, five additional genes have been genetically characterized PM100117 and PM100118 production, and to the accumulation of several derivatives Deletion of one of these genes led to a decay in Genes shows high identity to proteins involved in the biosynthesis of The basis of bioinformatics and genetic engineering data. PM100117 and PM100118 biosynthesis gene cluster, which has been characterized on ResultsĬaniferus GUA-06-05-006A has enabled the identification of Structurally, PM100117 and PM100118 are composed of a macrocyclic lactone, threeĭeoxysugar units and a naphthoquinone (NQ) chromophore that shows a clear Cf.PM100117 and PM100118 are glycosylated polyketides with remarkableĪntitumor activity, which derive from the marine symbiotic actinobacteria
an electronic device designed to accept data, perform prescribed mathematical and logical operations at high speed, and display the results of these operations. a republic consisting mainly of the island of Taiwan off the SE coast … UniversaliumĬomputer - computerlike, adj. People s Republic of, a country in E Asia. figurines made of porcelain or ceramic material … UniversaliumĬhina - /chuy neuh/, n. plates, cups, saucers, etc., collectively. a translucent ceramic material, biscuit fired at a high temperature, its glaze fired at a low temperature.
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Operation Green (Ireland) - Operation Green (German: Unternehmen Grün) often also referred to as Case Green (Fall Grün) or Plan Green (Plan Grün), was a full scale operations plan for a German invasion of Ireland in support of Operation Sea Lion (Unternehmen Seelöwe). It is the role of intelligence cycle security to protect the process… … Wikipedia National intelligence programs, and, by extension, the overall defenses of nations, are vulnerable to attack. Counterintelligence or counter intelligence (see spelling differences) (CI) refers to efforts made by intelligence organizations to prevent hostile or enemy intelligence… … WikipediaĬounter-intelligence - This article is a subset article of intelligence cycle security. The SIOP gave the President of the United States a range of targeting options, and described launch procedures and target sets… … WikipediaĬounterintelligence - This article is a subset article of intelligence cycle security.
Single Integrated Operational Plan - The Single Integrated Operational Plan (SIOP) was the United States general plan for nuclear war from 1961 to 2003. Single Integrated Operational Plan - Montage montrant le tir d un SLBM Trident dépuis son lancement par un sous marin nucléaire lanceur d engins jusqu à la rentrée des multiples têtes … Wikipédia en Français This page deals with Clandestine HUMINT operational techniques, also called tradecraft. Operational Zone of the Adriatic Littoral - Operationszone Adriatisches Küstenland (de) Operational Zone of the Adriatic Littoral Administrative district of Nazi Germany … WikipediaĬlandestine HUMINT operational techniques - The Clandestine HUMINT page deals with the functions of that discipline, including espionage and active counterintelligence. Operational risk management - See also: Risk management The term Operational Risk Management (ORM) is defined as a continual cyclic process which includes risk assessment, risk decision making, and implementation of risk controls, which results in acceptance, mitigation, or… … Wikipedia
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